The gram-negative bacterium Vibrio cholerae produces a protein, cholera toxin (Mr 90,000), that is responsible for the characteristic symptoms of cholera: extensive loss of body water and NaCl through continuous, debilitating diarrhea. If body fluids and NaCl are not replaced, severe dehydration results; untreated, the disease is often fatal. When the cholera toxin gains access to the human intestinal tract it binds tightly to specific sites in the plasma membrane of the epithelial cells lining the small intestine, causing adenylyl cyclase to undergo prolonged activation (hours or days).
a. What is the effect of cholera toxin on [cAMP] in the intestinal cells? Why?
b. Based on the information above, suggest how cAMP normally functions in intestinal epithelial cells. Briefly justify.
c. Suggest a possible treatment for cholera
Answer:
a.) It causes prolonged activation of adenylyl cyclase which leads to increased levels of Cyclic adenosine monophosphate(cAMP).
b.) In the intestinal epithelial cells, the cAMP binds to the apical chloride channels and allows it to open leading to osmotic permeability of water across the cell into the lumen of the intestine which is excreted through the faeces.
C.) Cholera can effectively be treated through the use of antibiotics and intravenous fluid replacement therapy.
Explanation:
Vibrio cholerae is a gram negative rigid curved bacillus that are actively ( vigorously) motion by a polar flagellation. The name vibrio is derived from the characteristic vibration movement of the organism when viewed under a microscope. This bacteria is capable of producing toxins called cholera toxin, which it uses as a virulent factor. It is responsible for the characteristic symptoms of cholera: extensive loss of body water and NaCl through continuous, debilitating diarrhea.
Cyclic adenosine monophosphate(cAMP) which is called a second messenger because it is not a hormone that can directly institute an intracellular change, instead, it serves as a second messenger to cause an effect.In the intestinal epithelial cells, the cAMP binds to the apical chloride channels and allows it to open leading to osmotic permeability of water across the cell into the lumen of the intestine which is excreted through the faeces.
In the effect of cholera toxin on the cAMP in the intestinal cells, Cholera toxin increases the fluid loss. The binding of the toxin to the intestinal cells causes a large increase in the level of cAMP in the cells by inhibiting the conversion of GTP bound to Ga to GDP. So adenyl cyclase is not turned off and diarrhea results.
The possible treatment is through the use of antibiotics and intravenous fluid replacement therapy. Prompt and adequate replacement of lost fluid and electrolyte through oral administration and supplemented with intravenous administration of fluids highly suggested for treatment of cholera. Antibiotics is equally used for treatment only when the cholera strain has been confirmed sensitive to it through culture.
what observations can be made and what can be concluded from these observations
Answer:
Correct option is A0 Based on the dispersion of white light into its constituent colours, we can conclude that (a) the white light consists of seven colours
Correct option isA0Based on the dispersion of white light into its constituent colours, we can conclude that (a) the white light consists of seven colours(b) the violet light suffers maximum deviation and the red light suffers minimum deviation.
Based on observations from dispersion, it can be concluded that white light is composed of seven colours of light.
What is dispersion of light?Dispersion of light is the separation of white light onto its constituent color as it passes through a refraction prism.
White Light consists of seven colours of varying wavelength.
When light is passed through a refracting prisms, dues the difference in the speed of the different constituents of light, seven colours of light are produced.
Therefore, based on observations from dispersion, it can be concluded that white light is composed of seven colours of light.
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In Drosophila, red eyes is wild-type and purple eyes are mutant. Full-size wings are wild-type and vestigial wings are mutant. Flies with wild-type pr pr vg vg genotypes were crossed with double mutant flies with a pr-pr- vg-vg- genotypes. The F1 flies had pr pr- vg vg- genotypes. The F1 flies with heterozygous genotypes were crossed with double mutant flies with a pr-pr- vg-vg- genotypes One thousand offspring were typed. This cross produced 430 red-eye, wild-type wing flies, 65 purple-eye wild-type wing flies, 60 red-eye, vestigial wing flies, and 445 purple-eye, vestigial wing flies. What is the distance between the loci for purple eyes and vestigial wings in centiMorgans (map units)
Answer:
Distance between genes → 12.5 MU = 12.5 cM.
Explanation:
Due to technical problems, you will find the complete explanation in the attached files.
Use the following list of organisms to create a food chain diagram.
•Hawk
•Toad
•Green plants
•Snake
Be sure to include the original source of energy for all living things in your diagram. Then, label each of the following: producer, primary consumer, secondary consumer, tertiary consumer.
Answer
green plants eaten by toad toad eaten by snake and snake eaten by hawk
green plants producer
toad primary consumer
snake secondary consumer
hawk tertiary consumer
Explanation:
Answer:
PRODUCER. > Green plants.
PRIMARY CONSUMER > Toad.
SECONDARY CONSUMER > Snake.
TERTIARY CONSUMER > Hawk.
Creating a checklist of activities is not a helpful strategy for determining what to study for an upcoming test. Please select the best answer from the choices provided T F
Answer:
ture
Explanation:
Answer:
true
Explanation:
edge 2021
Visit the link below and use the information to answer the following question.
Ecological Succession: Transformation of Communities over Time
Why does secondary succession occur faster than primary succession?
Answer:
Because there is already presence of soil and nutrients in secondary succession
Explanation:
Ecological succession, which is the series of gradual change that occurs in a community over time, can be of two forms namely: primary succession and secondary succession.
- Primary succession is a kind of succession that occurs in a barren land where no form of life has existed before while secondary succession occurs on a land that has been previously colonized by certain organisms called PIONEER SPECIES, and hence, a substrate containing nutrients called SOIL for growth is available during secondary succession.
This accounts for the reason the secondary succession is faster than the primary succession because there is already presence of soil and nutrients in secondary succession.
Answer:
Soil with nutrients is already present. Seeds are present from earlier occupants, brought in by wind, and/or germinate after fire.
Explanation:
Edge 2021
A major disturbance that caused the ecosystem to completely collapse.
Answer:
was when the snakes and the grass became diseased. A major disturbance that caused the ecosystem to stabilize at a new equilibrium. When there was an increase in the snakes and hawks.
Explanation:
When cells break down food glucose molecules during cellular respiration, energy is
Answer:
when cells break down food molecules, some of the energy on the molecules is released as heat. Cells use much of the remaining energy to make ATP. When glucose is broken down during cellular respiration energy is stored temporarily in molecules of ATP.
Explanation:
g It was noted in the Experimental Pathways feature in Section 10.4 that at least two- thirds of the human genome is derived from transposable elements. The actual number could be much higher, but it is impossible to make a determination about the origin of many other sequences. Why do you suppose it is difficult to make assignments about the origin of many of the sequences in the human genome
Answer:
TEs are repetitive and mobile elements, thereby it is hard to trace their origins
Explanation:
Repetitive elements are patterns of nucleotide sequences in the DNA characterized to have multiple copies throughout the genome. DNA mini-satellite and Transposable Elements (TEs) are some examples of highly repetitive DNA. TEs are repetitive mobile elements that have the ability to jump within the genome and occupy a major part of eukaryotic genomes. For instance, there is a type of TEs called retrotransposons which mobilize through a copy-and-paste mechanism, thus increasing their number in a genome. In consequence, TEs represent highly repetitive and dynamic genomic sequences, and thereby it is hard to trace their evolutionary histories.
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Water can be formed from the synthesis reaction of hydrogen with oxygen:
2 H2 (g) + O2 (g) → 2 H2O (g)
The complete reaction of 5.12 Liters of O2 with excess hydrogen produces how many moles of H2O?
A) 10.24 moles H2O
B) 114.7 moles H2O
C) 0.457 moles H2O
D) 5.12 moles H2O
Answer:
Explanation:
[2ΔSf(H2O (g))] - [2ΔSf(H2 (g)) + 1ΔSf(O2 (g))]
[2(188.72)] - [2(130.59) + 1(205.03)] = -88.77 J/
The wings of butterflies and birds are ----------- structures because, although they are used for the same purpose (flight) they have very different structural compositions. Bird wings are made of bones and feathers while butterfly wings are made from chitin and are part of the insect’s exoskeleton.
Answer:
symetrical
Explanation:
Most minerals are______at room temperature
liquid
gas
solid
Answer:
The answer should be solid
???????????????,,,??,???? What is the answer to number 4 and 5
Answer:
Questions 4-snow and 5 is rain showers
Name three benefits of keeping plants at home.
Answer:
Studies have shown that indoor plants...
Boost your mood, productivity, concentration and creativity.
Reduce your stress, fatigue, sore throats and colds.
Help clean indoor air by absorbing toxins, increasing humidity & producing oxygen.
Add life to a sterile space, give privacy and reduce noise levels.
Which of these climates is characterized by dense, lush vegetation, broadleaf plants, and high blodiversity?
A. Desert
B. Savanna
C Tundra
D. Rain forest
Answer: ITS AAAAAAAAAA
Explanation: A
Name the two main compounds that are exhaled (breathed out) by humans as a result of Aerobic Cellular Respiration
Answer:
carbon dioxide and oxygen
Explanation:
Carbon dioxide is the waste product of cellular respiration that you breathe out each time you breathe. Blood picks up oxygen and releases carbon dioxide in the lungs. The opposite takes place in the cells where the blood releases oxygen and picks up carbon dioxide.
CORRECT ANSWERS ONLY, IF YOU SEND ME A LINK TO A SITE YOU WILL BE REPORTED.
What does Earth’s revolution around the sun cause? *
Earth's phases
Earth's day & night
Earth's year
Moon day & year
Answer:
Earth's year is what Earth's revolution around the sun causes
I need help with this
Answer:
D
Explanation:
I graphed it
The radius is also 5 therefor it must =25
PLEASE HELP ASAP ILL GIVE YOU BRAINLIEST AND MOST HELPFUL!!
Answer:
the second choice is really the only on that makes sense,
Explanation:
I'm not really sure that plants need rocks but it can't be the third answer choice because soil is made up of cells and microorganisms. Plants can photosynthesize but animals (the mocking jay) cannot. and for the last choice water and sunlight aren't any type of organism, they are abiotic.
After synapsis, chromosomes may swap segments in a process called translocation.
True
False
Answer:
false
Explanation:
During synapsis, chromatids of homologous chromosomes exchange segments in a process called crossing over. This rearranges genetic info. As this phase continues the chromosomes coil tightly and a spindle forms.
Attitudes are ________
a. innate
b. generally positive
c. learned
d. unchangeable
1. FIG 1 shows four organisms which belong to the class Myriapoda
(し
C
A
B
(a) Name the phylum to which the class Myriapoda belongs. State two reasons for your answer
[3]
(b) Give the names of organism A and D.A.
D..........
[2]
(c) Differentiate between A and Din terms of structure
.. [3]
2. FIG 2 shows four different organisms
Answer:
sry can't amswer
sry sry
Which fact supports the conclusion that goats are crucial to the international food supply?
Americans use milk from goats to make cheese.
Most of the world’s milk comes from goats.
The flavor of a goat’s milk varies by its breed.
Many Americans prefer cow meat to goat meat.
Answer:
blanks
Explanation:
Answer:most of the world’s milk comes from goats
Explanation:
Explain why conflict avoidance does not help in sustaining positive relationship
Answer:
Avoidance is not healthy for sustaining the positive relationships as the ignorance or avoidance can cause the damage between the relationships of the people. The maintenance of the relationship among people can be hampered by avoidance. It can make the other people feel neglected. That can cause a failed relationship.
Explanation:
Identify three immune system organs and their functions.
Answer:
Primary lymphoid organs: These organs include the bone marrow and the thymus. They create special immune system cells called lymphocytes.
Secondary lymphoid organs: These organs include the lymph nodes, the spleen, the tonsils, and certain tissue in various mucous membrane layers in the body (for instance in the bowel). It is in these organs where the cells of the immune system do their actual job of fighting off germs and foreign substances.
Also...
Bone marrow is a sponge-like tissue found inside the bones. That is where most immune system cells are produced and then also multiply. These cells move to other organs and tissues through the blood. At birth, many bones contain red bone marrow, which actively creates immune system cells. Over the course of our life, more and more red bone marrow turns into fatty tissue. In adulthood, only a few of our bones still contain red bone marrow, including the ribs, breastbone, and pelvis.
POSSIBLE POINIS: 5
Which of the following is the best example of a population with the terrarium ecosystem?
A
the grains of sand in the bottom of the jar
B
the air and the screen at the top of the jar
С
the paper tube and the water containers
D
the three crickets in the jar
Answer:
A
Explanation:
Look at the following equation.
Na C02(s) + 2 HCl(aq) + 2 NaCl(aq) + CO2(g) + H2O(1)
What do the symbols in the equation mean?
(s) =
(aq) =
(g) =
(I) =
what would be a great research topic? related to biology.
Finding good research topics related to traditional biology subfields like animal and plant biology, ecology (current global problems warrant a number of hot topics), or topics related to humans: neurobiology (and determinants of human behavior), recent discoveries on diseases and the immune system, Animal health!
This is due, can you help me please!
A brown guinea pig mates with a white guinea pig. All of the babies have tan, or light brown fur. The hair color trait in guinea pigs is probably ____.
1. Sex linked
2. Recessive
3. Incomplete dominance
4. Codominant
Answer:
It would be sex linked.
Explanation:
As you know (if you do), when two animals mate, they combine their genes to make a baby. So of their skin colors are different like one is brown and one is white, then you get a baby that would look brownish white or have spots that are brown or white.