Answer:
The vitamin D receptor (VDR) is present in mammary gland, and VDR ablation is associated with accelerated glandular development during puberty. VDR is a nuclear receptor whose ligand, 1,25-dihydroxyvitamin D [1,25-(OH)(2)D] is generated after metabolic activation of vitamin D by specific vitamin D hydroxylases. In these studies, we demonstrate that both the VDR and the vitamin D 1-alpha hydroxylase (CYP27B1), which produces 1,25-(OH)(2)D are present in mammary gland and dynamically regulated during pregnancy, lactation, and involution. Furthermore, we show that mice lacking VDR exhibit accelerated lobuloalveolar development and premature casein expression during pregnancy and delayed postlactational involution compared with mice with functional VDR. The delay in mammary gland regression after weaning of VDR knockout mice is associated with impaired apoptosis as demonstrated by reductions in terminal deoxynucleotidyl transferase-mediated deoxyuridine nick-end labeling staining, caspase-3 activation and Bax induction. Under the conditions used in this study, VDR ablation was not associated with hypocalcemia, suggesting that altered mammary gland development in the absence of the VDR is not related to disturbances in calcium homeostasis. Furthermore, in the setting of normocalcemia, VDR ablation does not affect milk protein or calcium content. These studies suggest that the VDR contributes to mammary cell turnover during the reproductive cycle, and its effects may be mediated via both endocrine and autocrine signaling pathways. Unlike many mammary regulatory factors that exert transient, stage-specific effects, VDR signaling impacts on mammary gland biology during all phases of the reproductive cycle.
Explanation:
i-summarize niyo nalang po
which of the following suggestions would be most beneficial for a reader in order to gain a better understanding of the information presented in this excerpt? skim encyclopedias to learn star names and locations. review scientific journals explaining the various types of clouds. read a variety of sources about the formation of black holes. search web pages focused on personal encounters with black holes.
Answer:
C. Read a variety of sources about the formation of black holes
hope this helps!
Answer:
C. Read a variety of sources about the formation of black holes
Explanation:
Just did on Edge 22
In which region would an archaeologist be most likely to find evidence of roman roads?.
Answer:
saharan africa
Explanation:
. Roman roads are spread to northern Africa.
if the archeologist would go to sub Sahara Africa, he would be more likely to fijd the roads.
he could also go to Israel. the Roman's made a stone paved road and some people while traveling it dropped coins. if he were to look for the coins, he would find the road.
Research and development is an integral part of this organisation.
Research and development are activities addressed in order to develop new products, processes or services, being essential for the improvement of any business organization.
Research and development is related to investments to conduct research in technical and scientific knowledge.
The developments of these technologies are aimed at obtaining new products, processes or materials.The primary objective of research and development in the organization is to achieve innovations that drive increased sales.Therefore, we can conclude that research and development is applied to seek new scientific or technological knowledge that will then be used in an orderly manner by the organization.
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What's the correct entry to record a tool purchase of $500?.
The correct entry to record a tool purchase of $500 is Debt tools expense $500, Credit cash $500
From the complete question, the purchase price is given as:
Greater than $1000
The above entry would be recorded as follows:
Debt tools Credit cash.For each entry, the amount is one-half of the amount of the tool purchase In other words, the half of $1000 ($500)
Hence, the correct entry to record a tool purchase of $500 is Debt tools expense $500, Credit cash $500
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A bank that has not received payment on a loan can try to get its money back by:.
A bank that has not received payment on a loan from a borrower can try to get its money back by: hiring a collection agency to retrieve (seize) the money from the borrower.
A loan refers to an amount of money that is borrowed from a lender such as a financial institution (bank) and it is expected to be paid back at an agreed date with a predefined interest.
Generally, a financial institution (bank) lending out a sum of money to a borrower usually require that, the borrower provides a collateral which would be taken over in the event that the borrower defaults (fails) in the repayment of the loan.
Additionally, a collection agency can be hired by a bank to retrieve (seize) the money from the borrower when it hasn't received payment on a loan from a borrower.
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Answer: Hiring a collection agency to seize the money from the borrower
Explanation: correct on a p e x
The imagery in these lines evokes a sense of laziness. Fear. Mystery. Despair.
There are different kinds of lines. The imagery in these lines evokes a sense of Mystery.
For better understanding, lets explain MysteryA sense of mystery is simply referred to as anything that is kept hidden or remains a secret. Example is the mysteries of nature. any affair, etc. This tends to raise curiosity or different kinds off speculation.
It arises if and when a specific situation is shown or depicted in the writing seem unclear and difficult to explain.The use of the word darkness in both lines shows that something is not seen and the use of the words 'settles' and 'calls' implies that the speaker is present in the darkness.
See full question belowDarkness settles on roofs and walls, But the sea, the sea in darkness calls; The imagery in these lines evokes a sense of laziness. fear. mystery. despair.
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Answer:
C
Explanation:
What is the value of x in the equation ?.
Answer:
There is no equation provided
Explanation:
Which stage direction from part one of trifles most adds to the suspenseful tone?.
Answer:
uhhh left stage direction
Answer:
Edge2022
D. MRS. PETERS (starts to speak, glances up, where footsteps are heard in the room above. In a low voice.)
Explanation:
Explain one way in which barbot’s background might have influenced his comments about the dutch and the portuguese in the second paragraph.
One way Barbot's background may have influenced his comments on the Dutch and the Portuguese is that; he had a protestant background which was also synonymous with the dutch whereas the Portuguese had catholic background which he could not relate with.
Jean Barbot was a French Protestant and an agent of the chartered Senegal Company who wrote a book about his travels in west africa.
The second paragraph being referred to here talks about how the castle at Elmina was brought to its perfect state under the Dutch after they captured it from the Portuguese in the year 1637.
Due to what he observed, he also said that it was a proof that the Dutch are the most curious and the most capable to make settlements abroad among all European nations.
The way his background may have affected his comments is that he had a protestant background which was also synonymous with the dutch whereas the Portuguese had catholic background which he could not relate with.
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Find the area of the triangle qrs. Area = square units.
[tex]\purple{\sf Area _{(Triangle)} = \: \dfrac{1}{2} \times Height \times \: Base \: Square \: units} [/tex]
Answer:
140
Explanation:
edge :))))
Which statement describes the 3d, 4s, and 4p orbitals of arsenic (as) based on its electronic configuration and position in the periodic table?.
The statement that describes the 3d, 4s, and 4p orbitals of arsenic (as) based on its electronic configuration and position in the periodic table is; The 3d and 4s orbitals are completely filled, and the 4p orbital is partially filled.
The electronic configuration of arsenic is given as; 1s² 2s² 2p^(6) 3s² 3p^(6) 4s² 3d^(10) 4p³.
Now we can see that in that electronic configuration the orbitals are, s, p and D.
Now, the maximum electrons for each of the 3 orbitals are;
Maximum electrons for d orbital = 10 electrons
Maximum electrons for s orbital = 2 electrons
Maximum electrons for p orbital = 6 electrons.
Now, when we compare the maximum number of electrons for each orbital to the ones in electron configuration of arsenic, it is clear from the last 3 orbitals that the 3d and 4s orbitals are completely filled while the 4p orbital is half filled or partially filled.
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You are performing an experiment in a lab to attempt a new method of producing pure elements from compounds. The only problem is that you do not know what element will form. By your previous calculations you know that you will have 6. 3 moles of product. When it is complete, you weigh it and determine you have 604. 4 grams. What element have you produced?.
Answer:
molybdenum (Mo)
Explanation:
For this question you need to understand what the concept of molar mass is.
Molar mass is the exact mass by which you will obtain a mol of that specific element. For example the molar mass of H2O is 18g/mol, so it means that in 18 grams of water, you exactly have 6.022x10²³ molecules of water or one mole.
So here you know the number of moles you produce and its conversion to grams. The problem is basically stating that in 604.4 grams of x element you have 6.3 moles of that element.
All you have to do is divide the number of grams by the number of moles:
604.4grams/6.3 moles=95.94 g/moles,
You obtained the molar mass of that X element, and in fact the molar mass corresponds the molecular mass of all elements, that is an information provided by the periodic table. So all you have to do is look for the element with a molecular mass of 95.94 uma or a very close approximate.
Molybdenum has a molecular mass of 95.95. So that's the answer.
A syringe contains 0. 65 moles of he gas that occupy 850. 0 ml. What volume (in l) of gas will the syringe hold if 0. 35 moles of ne is added?.
Answer:
im sorry
Explanation:
(not really we will never meet in person)
Which orbital notation correctly represents a noble gas in the ground state?.
It should be noted that the orbital notation correctly represents a noble gas in the ground state is 2,8 and also [Ar]4s1
Noble gas can be regarded as one of the chemical elements in the periodic table.
Some of the elements in this group are;
ArgonHeliumTherefore, the orbital notation correctly represents a noble gas in the ground state is 2,8
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At a football game, the ratio of filled seats to empty seats was 7 to 3. The capacity of the stadium is 70,580. How many seats were filled for the game?.
The number of seats in the stadium that were filled for the game is equal to 49,406 seats.
Let the filled seats be F.Let the empty seats be E.Given the following data:
Stadium capacity = 70,580.Ratio of F to E = 7:3Total ratio= 7 + 3 = 10To determine the number of seats in the stadium that were filled for the game:
Mathematically, the number of filled seats in the stadium is given by this expression:
[tex]F = \frac{7}{10} \times 70580\\\\F=0.7 \times 70580[/tex]
F = 49,406 seats.
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Which phrase best describes the harlem renaissance?.
Answer:
The Harlem Renaissance was an intellectual and cultural revival of African American music, dance, art, fashion, literature, theater and politics centered in Harlem, Manhattan, New York City, spanning the 1920s and 1930s.
I hope this helps you !!Complete the following paragraph about the battles in the pacific theater brainly.
There are different kinds of war. Japan aimed at conquering the small islands in the Pacific Ocean one by one. This strategy of controlling one small island after another is called Island Hopping.
The US is known to have implemented island hopping so as to be able to defeat Japan.The United States was known to have invented a plan called “Island Hopping”. Through which they aimed to have military bases and secure as many small islands in the Pacific.
See full question below
Fill in the blank in this paragraph about the Pacific Theater of World War II.
Japan aimed at conquering the small islands in the Pacific Ocean one by one. This strategy of controlling one small island after another is called _____
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Which ion/molecule in the saliva allows you to taste sugar as sweet weegy.
Saliva is made up of 99% water, the water molecules helps dissolve food and allows to perceive flavors through the sense of taste.
The food that is introduced into the mouth is dissolved in the saliva, penetrating the taste buds through the pores in the tongue.
The aqueous content where the water molecules represent more than 99% allow the taste receptors to be reached and there is ion exchange for the flavor to be captured.The individual molecules to perceive the sweet taste are released after moistening the food with saliva, this function is determined by the water.Therefore, we can conclude that saliva acts on the taste function since the water content can determine the level of dilution of basic flavors such as sweet.
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Explain the relationship between energy and economic development. Brainly.
Would you use sss or sas to prove the triangles congruent? explain. If there is not enough information to prove the triangles congruent, choose not enough information.
Answer: SSS; two congruent sides are given and the 3rd side is congruent by the Reflexive Property of Congruence.
Explanation: so you would use SSS
Two numbers differ by 8 if their product is 713 then the sum of the two numbers is.
The sum of the two numbers is equal to 70.
Let the first number be x.Let the second number be y.In this exercise, you're required to find two numbers by translating the word problem into an algebraic expression and then solving for the unknown variables (x and y).
Translating the word problem into an algebraic expression, we have;
Two numbers differ by 8:
[tex]x-y=8[/tex] ....equation 1.
The product of the two numbers is 713:
[tex]xy=713[/tex] ....equation 2.
To calculate the sum of the two numbers:
First of all, we would solve for each of the unknown variables (x and y).
From eqn. 1, we have:
[tex]x=8+y[/tex] ....equation 3.
Substituting eqn. 3 into eqn. 2, we have:
[tex]y(y+8)=713\\\\y^2+8y=713\\\\y^2+8y-713=0[/tex]
Solving the quadratic equation by factorization, we have:
[tex]y^2-31y +23y-713=0\\\\y(y-31)+23(y-31)=0\\\\(y+23)(y-31)=0[/tex]
y = -23 or 31.
For the value of x, when y = 31:
[tex]x=8+31[/tex]
x = 39
Now, we can calculate the sum of the two numbers:
[tex]x+y=39+31=70[/tex]
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Lorena and julio purchased a home for $205,950. Their loan amount was $164,760, and the assessed value is now $200,500. Their tax rate is 1. 5%. How much will their monthly taxes be?.
What is the atomic mass of the element in period 2 group 13.
Answer:
thire is no grup 13 in modern periodic table
Which is the best strategy when you find too much information.
Answer:
Ignore them, just like I have been ignoring your questions. Can't you answer any questions at all without posting them all on Brainly, or are you just too lazy to answer them?
Amino acids have one thing that makes them different from each other. What is it.
The side groups are what make each amino acid different from the others. Of the 20 side groups used to make proteins, there are two main groups: polar and non-polar. These names refer to the way the side groups, sometimes called "R" groups, interact with the environment.
Jose and zola want to purchase their first home. Jose makes $23. 50 an hour and works 40 hours per week. Zola makes $21. 50 an hour and works 40 hours of regular time and for the last three years, has also worked on average 5 hours of overtime a week. They have two car payments totaling $500 a month and one credit card with a minimum payment of $50 a month. What is their combined gross monthly income?.
Based on the computation done, the value of the combined gross monthly income is $7630.
Since there are four weeks in a month, Joe's income will be:
= 23.50 × 40 × 4
= 3760
The value of Zola's income will be:
= 21.50 × (40 + 5) × 4
= 21.50 × 45 × 4
= 3870
Therefore, the combined gross monthly income will be;
= $3760 + $3870
= $7630
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Harmony of the design is ensured by _______________ design principle.
The design principle that ensures Harmony of the design is; Theme
Harmony of the design is simply defined as the concept whereby all the elements and principles of design work together to display visually pleasing garment.
Now according to principles of design, this concept of harmony of design is usually ensured by the theme design principle. This is because the theme design principle is the only one that ensures a display of visually pleasing garment.
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A food worker has an earache a few hours before he is scheduled to work.
Answer:
If the earache is unbearable, wait to call in as "sick" until later to make sure that it does not go away and you can go to work.
Wait till later to call in as "sick" if the earache is excruciating to ensure that it won't go away and you can still go to work.
Who Is a Worker?Workers are those hired by a company or industry who are not managers. Workers have been laid off and wages were frozen. A rallying cry for all workers everywhere. The agreement promotes employee input into management decisions.
Workers are organizational personnel who physically carry out work in the organization and put plans set by the organizational management into action. Workers use a variety of tools, equipment, instruments, methods, and processes to do it.
First and foremost, every worker has the legal right to be spared an unfair dismissal.
2. to be accorded respect and decency.
3. to receive payment of the agreed-upon wage at the scheduled time and day.
4. to receive the tools and resources needed to do the task, including the right training.
5. to enjoy secure working circumstances.
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What is the most appropriate unit for the length of a pencil.
Answer:
inches
Explanation:
because centimeters is to small and inches is easier to count
When faxing sensitive compartmented information (sci), what actions should you take?.
When faxing sensitive compartmented information (sci), the actions you should take are;
Make sure the SCI's are encrypted.Only those with the necessary security clearance will have the decryption keys to unlock them. Sensitive Compartmented Information(SCI) is a classified information that is derived from sensitive intelligence sources, methods, or analytical processes.SCI is always required to be handled within formal access control systems that are established by the US Director of Central Intelligence.
SCI's are usually very sensitive information as most of them contain information of national security interest and as such should be kept hidden and only open to those meant to read it. Thus, when SCI's are to be faxed, the action to be taken is that they should be encrypted in such a way that only those with the necessary security clearance will have the decryption keys to unlock them.Read more about Sensitive Compartmented Information(SCI) at; https://brainly.com/question/25194168