The decision to perform two separate operations, copying the value from the memory data register (MDR) to the H register and then subtracting it from the top of the stack (TOS), instead of using a single comparison statement, might be attributed to the architecture and design choices of the Mic-1 microprogram.
One possible reason is that the Mic-1 microprogram architecture follows a more modular and sequential approach. By separating the steps into distinct microinstructions, it allows for better control and flexibility in handling intermediate results or performing additional operations before executing the comparison.
Additionally, breaking down the operations into separate steps might simplify the microinstruction sequencing and control logic, making it easier to implement and optimize. It could also allow for better error detection and handling by checking intermediate states during execution.
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Explain how the presence of silica affects the viscosity of
magma.
The presence of silica affects the viscosity of magma because silica is a polymerizing agent that forms a cross-linked structure with other minerals in the magma. The more silica present in the magma, the higher the viscosity. Viscosity refers to the resistance of a fluid to flow. Silica creates a network of bonds within the magma, which makes it more difficult for the molten rock to flow. The network of bonds increases with the addition of more silica.
The viscosity of the magma increases as the silica content increases.The magma with higher silica content tends to be more viscous. If there is a high silica content in the magma, it will be more resistant to flow, which can lead to explosive eruptions. When the magma contains less silica, it is easier for the molten rock to flow out of the volcano, resulting in less explosive eruptions.In summary, silica affects the viscosity of magma as it forms a network of bonds within the molten rock.
The more silica present in the magma, the more viscous the magma becomes. The magma's viscosity determines the type of volcanic eruption that can occur.
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Plants living in regions where water supplies in the soil are low develop various adaptations to aid in their survival. Suggest FOUR of these adaptations.
Plants living in regions with limited water availability have evolved various adaptations to cope with the challenging conditions.
Four common adaptations seen in such plants:
1)Succulence: Many plants in arid regions have evolved succulent structures to store water.
These plants typically have fleshy leaves, stems, or roots that can store significant amounts of water during periods of rainfall.
The stored water can then be utilized during times of drought, allowing the plant to survive extended periods without rainfall.
2)Reduced leaves or spines: To minimize water loss through transpiration, plants in arid environments often have reduced leaves or modified leaf structures.
For example, some plants have small, needle-like leaves or spines that help reduce the surface area exposed to the hot and dry air, thereby reducing water loss.
3)Deep root systems: Plants adapted to arid conditions often possess deep root systems that enable them to access water from deeper soil layers.
These extensive root systems can tap into groundwater sources or reach areas with higher moisture content, allowing the plant to survive when surface water is scarce.
4)CAM photosynthesis: Crassulacean acid metabolism (CAM) is a specialized form of photosynthesis that many arid-adapted plants employ.
CAM plants open their stomata and take in carbon dioxide during the night when temperatures are cooler and water loss through transpiration is reduced.
They store the carbon dioxide as an organic acid and utilize it during the day for photosynthesis when the stomata remain closed to conserve water.
These adaptations enable plants to conserve and efficiently utilize water, enhancing their chances of survival in regions with low water supplies.
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Please help and thank you whoever you are
Answer: Should be 3
carolus linnaeus used the plant and animal kingdoms to classify organisms in the 1700s. what was the most likely reason for only having a 2 kingdom system at that time.
The most likely reason for Carolus Linnaeus having a two-kingdom system for classifying organisms in the 1700s was due to limited knowledge and understanding of the diversity of life on Earth at that time. Linnaeus developed his classification system based on observable physical characteristics of organisms, primarily focusing on plants and animals. The understanding of microorganisms, such as bacteria and fungi, was limited during Linnaeus' time, and their classification into separate kingdoms was not yet established.
Additionally, Linnaeus based his classification system on the concept of a hierarchical organization, where organisms were grouped into broader categories based on similarities and differences in their characteristics. The two-kingdom system of plants and animals provided a simplified framework for organizing and categorizing the known organisms.
As scientific knowledge advanced and more discoveries were made, the limitations of the two-kingdom system became apparent. The development of microscopy and the discovery of microorganisms led to the recognition of a separate kingdom for bacteria and later the inclusion of fungi as a separate kingdom. Over time, the classification system evolved and expanded to accommodate the growing understanding of the diversity of life forms, eventually leading to the development of the modern classification systems with multiple kingdoms and domains.
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for a person deprived of water, the satisfaction that follows drinking a thirst-quenching beverage best illustrates
For a person deprived of water, the satisfaction that follows drinking a thirst-quenching beverage best illustrates the concept of homeostasis.
Homeostasis is the maintenance of a stable internal environment in an organism, and the desire to drink water is a response to an imbalance or disturbance in homeostasis caused by dehydration. The deprivation of water is often associated with thirst. Dehydration causes the body to crave water, and drinking a thirst-quenching beverage brings relief and satisfaction to the body. This response is due to the body's natural tendency to maintain a balance of water and electrolytes, which is essential for proper bodily functions such as regulating body temperature, blood pressure, and metabolism.
Drinking a beverage to satisfy thirst also activates the reward and pleasure centers in the brain, leading to a subjective feeling of satisfaction and relief. This response is mediated by various physiological and psychological factors, including the release of neurotransmitters and the perception of quenching one's thirst.
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What do Astronauts need to take on the moon so that plants could grow in a lunar plant growth chamber
Explanation:
What is the name of this website or the book?
Astronauts need to take water to take on the moon so that the plants could grow in a lunar plant growth chamber.
What affects lunar plant growth chamber?Plants can be grown in the lunar regolith. Plants grown on the moon were not as robust as the plants which are grown in soil of the Earth, or even as those in the control group grown in a lunar simulant made from the volcanic ash, however they did indeed grow well.
Real lunar and the Martian regolith seem to contain all the essential ingredients which are required for the growth of plant. However, there is a very small amount of reactive nitrogen and growing food materials in it that requires a large amount of water. Regolith can only store up to thirty percent of the water which organic soil of the Earth can store.
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During the development phase of an intervention, which type of validity is especially salient?
A. Statistical conclusion validity.
B. External validity.
C. Construct validity.
D. Internal validity.
During the development phase of an intervention, construct validity is particularly important in ensuring the accurate assessment and representation of the underlying theoretical constructs.
In the development phase of an intervention, the focus is on establishing the theoretical foundation and refining the intervention to effectively address the intended constructs. Construct validity becomes salient as it ensures that the intervention accurately captures and measures the desired constructs. This involves defining the constructs clearly, selecting appropriate measurement tools, and establishing a strong theoretical framework.
By prioritizing construct validity during development, researchers and developers can lay a solid foundation for subsequent evaluation and implementation stages, ensuring that the intervention is meaningful, aligned with its goals, and capable of addressing the intended constructs effectively.
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Seasonal changes occur when the Earth moves so that the Northern Hemisphere and the Southern Hemisphere are tilted more toward or away from the Sun. If the Northern Hemisphere is tilted toward the Sun and it is summer, what is happening in the Southern Hemisphere?
A. The Southern Hemisphere is tilted toward the Sun, and it is summer.
B. The Southern Hemisphere is tilted away from the Sun, and it is summer.
C. The Southern Hemisphere is tilted toward the Sun, and it is winter.
D. The Southern Hemisphere is tilted away from the Sun, and it is winter.
Answer:
D
Explanation:
the southern hemisphere is always doing the opposite of the northern hemisphere
All of the following statements about the "blender experiment" is true except
A. The experiment preceded Watsons and Crick's elucidation of DNA structure.
B. Hershey and Chase used radioactive sulfur to follow the protein in their experiment.
C. Hershey and Chase used radioactive phosphorus to follow the nucleotides in their experiment.
D. It was discovered by them that while different strains of bacteria have different percentages of nitrogen bases, the percent of adenine and the percent of thymine are equal as are the percentages of guanine and cytosine.
E. Hershey and Chase experiment lent strong credence to the idea that DNA is the hereditary material, at least of viruses.
The statement that is not true about the blender experiment is it was discovered by them that while different strains of bacteria have different percentages of nitrogen bases, the percent of adenine and the percent of thymine are equal as are the percentages of guanine and cytosine, option D is correct.
It was not discovered by Hershey and Chase in their experiment that the percentages of adenine and thymine are equal, as well as the percentages of guanine and cytosine. This discovery was actually made by Erwin Chargaff, who observed the base composition of DNA from various species and found that the amount of adenine is roughly equal to thymine, and the amount of guanine is roughly equal to cytosine.
Hershey and Chase's experiment, on the other hand, provided strong evidence for DNA being the hereditary material, specifically for viruses. They used radioactive phosphorus to label the DNA and radioactive sulfur to label the protein, showing that viral DNA, not protein, enters host cells during infection, option D is correct.
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Which statement is NOT correct?
Select an answer and submit. For keyboard navigation, use the up/down arrow keys to select an answer.
miRNA is an endogenous gene editing system found in prokaryotes.
b
siRNA is noted for perfectly binding to mRNA.
C As originally discovered, CRISPR acts as a foreign DNA interference system.
d Misfolded proteins can be targeted for destruction if they are polyubiquitinated.
The claim that prokaryotes have an inherent gene editing mechanism called miRNA is untrue. Here option A is the correct answer.
miRNA (microRNA) is not an endogenous gene editing system found in prokaryotes. miRNAs are small, non-coding RNA molecules that play a role in post-transcriptional gene regulation in eukaryotic organisms. They are involved in the regulation of gene expression by binding to messenger RNA (mRNA) and inhibiting its translation or promoting its degradation.
On the other hand, prokaryotes do possess their own gene editing systems, such as CRISPR-Cas systems, which are adaptive immune systems that provide defense against foreign genetic elements like viruses. CRISPR-Cas systems were originally discovered as a foreign DNA interference system in prokaryotes.
siRNA (small interfering RNA), mentioned in option b, is indeed noted for perfectly binding to mRNA, leading to its degradation and subsequent inhibition of gene expression.
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Complete question:
Which statement is NOT correct?
a) miRNA is an endogenous gene editing system found in prokaryotes.
b) siRNA is noted for perfectly binding to mRNA.
c) As originally discovered, CRISPR acts as a foreign DNA interference system.
d) Misfolded proteins can be targeted for destruction if they are polyubiquitinated.
Name two types of a sexual
reproduction which occur in animals
giving one example in each case
Answer:
Meiosis and Fertilization
sexual and asexual reproduction
Throughout the year, areas of the Earth's surface are either tilted away from the Sun or toward the Sun. This is a result of the Earth tilting on its axis. What is the main impact of this phenomenon?
A. It causes tides.
B. It generates winds.
C. It produces seasons.
D. It influences ocean currents.
What is the scientific name for recycled yard waste?
Answer:
compost
Explanation:
TRUE/FALSE. the decapitated plant shoot would have grown straight up with no bending after the block was placed squarely on top of the cut plant shoot surface.
The statement, "the decapitated plant shoot would have grown straight up with no bending after the block was placed squarely on top of the cut plant shoot surface" is False.
Decapitation refers to the complete removal of an organism's head. The decapitated organism will die immediately if the brain is removed or damaged. It's a major issue in the plant world. When a plant is decapitated, it exhibits certain behaviors. Plants react to decapitation in a variety of ways. When a plant is decapitated, it will usually generate a wound response, which will begin with a surge of auxin hormone signaling from the site of the wound.
After decapitation, the plant's stem, which is severed from the rest of the plant's tissues, undergoes considerable alterations. Some plants might increase the growth of branches, whereas others might generate new shoots. Instead of growing straight up, the decapitated plant shoot would have bent. The study demonstrates that the removal of the plant's primary shoot apical meristem caused a surge in growth hormones in the nearby side buds. These side buds grew into new branches, resulting in a bushier plant. A block placed squarely on top of a cut plant shoot surface has no effect on the growth direction of the plant.
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experiment 1: what was the final color of the diffusion bag?
Experiment 1 was an experiment to observe the effects of osmosis on a plant cell. In this experiment, the diffusion bag, made of a semi-permeable membrane, was filled with starch and glucose solutions.
Experiment 1 was an experiment to observe the effects of osmosis on a plant cell. In this experiment, the diffusion bag, made of a semi-permeable membrane, was filled with starch and glucose solutions. The experiment was conducted in two parts. In the first part, the bag was placed in distilled water, and in the second part, it was placed in a sucrose solution. The purpose of the experiment was to determine whether water moves from an area of low solute concentration to an area of high solute concentration or vice versa. This movement of water is known as osmosis.The final color of the diffusion bag in experiment 1 was black. The starch and glucose solutions were both clear and colorless, but when they mixed, they formed a black substance. This was because the glucose reacted with the iodine solution, which was added to the bag as an indicator. Iodine turns blue-black in the presence of starch. Since the starch and glucose solutions mixed inside the diffusion bag, the iodine solution reacted with the starch and turned black. The diffusion of the substances through the semi-permeable membrane was evident in the color change of the contents of the bag.
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which of the following choices reflects the appropriate order of locations through which a protein destined for the plasma membrane travels?
The order of locations through which a protein destined for the plasma membrane travels is Golgi apparatus, Endoplasmic reticulum.
Protein trafficking refers to the process by which proteins are transported to their destination after synthesis. Following translation, a protein is conveyed to the Golgi apparatus through vesicular transport. The transport is mediated by coat proteins and small GTPases. Once a protein is in the Golgi, it is sorted to its final destination. Proteins destined for the plasma membrane travel through the trans-Golgi network and finally reach the plasma membrane.In eukaryotic cells, the endoplasmic reticulum (ER) is the organelle where the majority of secretory and membrane proteins are synthesized. The ER is also the site of post-translational modifications like folding and glycosylation, which are necessary for the proteins to attain their correct conformations. It is in the rough endoplasmic reticulum that secretory proteins, such as those for export outside of the cell, are synthesized.
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What are three of the products whales are hunted for by the whalers and their substitute products?
You are trying to collect an overdue payment of R163,00 on a shipment of milk powder to the Dominican Republic. A senior government official ask for R20, 000 as a collection service fee. Should you pay? Is illegal or legal?
As a business owner, it can be challenging to collect overdue payments from clients and customers. The situation becomes more complicated when a senior government official demands a service fee to collect the money owed.
From a legal perspective, it is illegal for a government official to demand payment for providing a service. It is important to remember that it is the government official's job to perform the duties of their position, which includes enforcing regulations and laws. Therefore, it is illegal to demand additional compensation for carrying out official duties.
Additionally, paying a collection service fee to a government official can be considered a bribe, which is also illegal. If the payment is made, it may result in negative consequences, such as legal charges or damage to the reputation of the business.
In conclusion, the business owner should not pay the collection service fee of R20, 000. It is illegal, and it could result in negative consequences for the business. Instead, the business owner should seek legal advice on how to proceed with collecting the overdue payment.
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the two traditional modes of genetic engineering may result in alterations of:
The two traditional modes of genetic engineering may result in alterations of the genetic information.
Traditional modes that result in genetic transformation:
Transgenic or Gene Addition: In this mode, a gene from one organism is introduced into the genome of another organism. This process can result in alterations of several aspects, including:
Phenotypic Traits: The introduced gene can express a new protein or modify the expression of existing proteins, leading to changes in the phenotypic traits of the organism. For example, the introduction of a gene for insect resistance into a crop plant can alter its resistance to pests.Metabolic Pathways: The introduced gene can encode enzymes that participate in metabolic pathways, affecting the production or breakdown of specific compounds within the organism. This can lead to alterations in the metabolic profile of the organism.Developmental Processes: If the introduced gene is involved in developmental processes, such as regulating the timing or pattern of growth, it can result in modifications in the organism's development and morphology.Gene Editing: In this mode, specific changes are made to the organism's own DNA sequence. The alterations that can occur through gene editing include:
Gene Knockout: By using techniques like CRISPR-Cas9, specific genes can be targeted and disrupted or deleted. This can result in the loss or reduction of function of the targeted gene, which may lead to phenotypic changes.Gene Insertion or Modification: Gene editing techniques can also be used to insert new genetic material or modify existing genes within the organism's genome. This can lead to alterations in protein expression or the functioning of specific genes, impacting various biological processes.The alterations resulting from traditional modes of genetic engineering are aimed at introducing desired traits or modifying specific characteristics of an organism for various purposes, such as improving crop yields, enhancing disease resistance, or producing valuable proteins. It's important to note that the effects of genetic engineering can vary depending on the specific genes and organisms involved and the intended modifications.
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Neurotransmitters that open Na+ channels and trigger action potentials in receiving cells are called
a. Inhibitory
b. Cross-linked
c. Excitatory
d. Blocked
e. Obligatory
The correct option is (c). Neurotransmitters that open Na+ channels and trigger action potentials in receiving cells are called Excitatory.
Neurotransmitters that open Na+ channels and trigger action potentials in receiving cells are called Excitatory. Na+ ion channels get opened by Excitatory neurotransmitters, such as glutamate or acetylcholine, allowing positively charged ions to flow into the cell. As a result, a membrane potential changes in an excitatory direction, which raises the likelihood of the target neuron firing an action potential. An action potential is a brief but substantial change in the voltage of a neuron that travels down the neuron's axon, resulting in the release of neurotransmitters from the axon terminal, which stimulates downstream neurons. They are responsible for propagating signals across the synapses that connect neurons. In conclusion, these neurotransmitters that open Na+ channels and trigger action potentials in receiving cells are called excitatory, and they play an important role in the transfer of information between neurons.
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11. Look at the Hawaiian islands inset. What is the distance between oldest and youngest Hawaiian island?
12. How many years has it taken for the Hawaiian islands to form?
13. What was the average rate of plate movement of the Pacific plate during the time when the Hawaiian island chain form ( in in/YR )? Note measure a straight line between Hawaii and Kawai do not measure between each individual island. (1mi=5280 ft and 1ft = 12 in) show work.
14. Using the rate you calculated in questions 10 and 13, write a brief statement that compares the average rate of movement of the Pacific plate today with what it was in the past.
15. What direction was the plate moving 50 million years ago?
16. What direction is the Pacific plate moving today?
11. The distance between the oldest and youngest Hawaiian island is approximately 3,500 kilometers (2,175 miles).
12. It has taken millions of years for the Hawaiian islands to form, with estimates ranging from 70 to 80 million years.
13. The average rate of plate movement of the Pacific plate during the formation of the Hawaiian island chain is approximately 6 centimeters per year (2.36 inches per year).
14. The average rate of movement of the Pacific plate today is similar to the rate during the formation of the Hawaiian island chain, which is around 6 centimeters per year (2.36 inches per year).
15. 50 million years ago, the Pacific plate was moving in a northwestern direction.
16. Today, the Pacific plate is moving in a northwestern direction.
Explanation to the above given short answers are written below,
11. The distance between the oldest and youngest Hawaiian island is approximately 3,500 kilometers (2,175 miles). This can be observed by looking at the Hawaiian islands inset on a map or by measuring the distance between the two points.
12. It has taken millions of years for the Hawaiian islands to form. Geologists estimate that the volcanic activity that created the islands began around 70 to 80 million years ago.
Over time, the volcanic eruptions built up the islands, and through a process called plate tectonics, the movement of the Pacific plate carried the islands to their current positions.
13. To calculate the average rate of plate movement during the formation of the Hawaiian island chain, we need to convert the given measurements to the same units.
Given that 1 mile is equal to 5,280 feet and 1 foot is equal to 12 inches, we can convert the rate from inches per year to centimeters per year. Therefore, 2.36 inches per year is approximately 6 centimeters per year.
14. The average rate of movement of the Pacific plate today is similar to the rate during the formation of the Hawaiian island chain, which is around 6 centimeters per year.
This suggests that the plate movement has remained relatively constant over millions of years. It indicates a steady process of volcanic activity and the creation of new land in the form of volcanic islands.
15. Approximately 50 million years ago, the Pacific plate was moving in a northwestern direction. This movement contributed to the formation and growth of the Hawaiian island chain as the volcanic hotspot beneath the plate produced a series of volcanoes that eventually formed the islands.
16. Today, the Pacific plate is still moving in a northwestern direction. The motion of tectonic plates is driven by convection currents in Earth's mantle.
The northwestern movement of the Pacific plate continues to shape the geological features of the Pacific Ocean, including the Hawaiian islands, and influences seismic activity and the formation of new land.
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Geranium leaves grow in positions that permit the optimum use of light as a result of
Answer:
do you work stop cheat broo this evan btw
Explanation:
Geranium leaves are typically arranged in a way that allows for optimal use of light through a process called "heliotropism" or "solar tracking."
What is heliotropism?Heliotropism is the ability of plants to orient themselves towards the direction of the sun to optimize their exposure to light.
Geranium leaves are arranged in a rosette pattern, with each leaf emerging from the base of the stem and spreading outwards. The leaves are arranged in a way that maximizes their surface area while minimizing shading of other leaves. This arrangement allows the leaves to capture the maximum amount of sunlight possible.
Additionally, geranium leaves have a waxy cuticle that helps to prevent excessive water loss and damage from UV radiation. The leaves also have chloroplasts, which contain chlorophyll and are responsible for photosynthesis, the process by which plants use sunlight to produce energy.
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A garden contains 40 flowers, 30 of which are red. What is the frequency of red flowers?
Answer:
0.75
Explanation:
a frequency of 1.0 occurs when all the flowers are red
A garden that contains 40 flowers, 30 of which are red. Then, the frequency of red flowers is 75% of 1:3.
What is Frequency?Frequency is the number of occurrences of a repeating event per unit time. It is also referred to as the temporal frequency for clarity, and is distinct from angular frequency. Frequency is usually measured in hertz (Hz) which is equal to one event per second.
Gene frequency is the fraction or percentage of a population which carries a particular allele at a particular gene locus. In this case, a garden has 40 flowers, in which 30 are red.
Therefore, the frequency of red flowers = Number of red flowers/ Total number of flowers
The frequency of red flowers = 30/ 40 = 75% or 1/3
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explain why the blood of an insect does not contain respiratory pigments
Answer:
Explanation: Respiratory pigments like haemoglobin, haemocyani, are needed for transport of respiratory gasses. In insects there is no such pigment in blood, because oxygen is directly delivered to cells by trachea!
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virus-infected cells produce ________, proteins that help neighboring cells fight further viral infections. group of answer choices histamines interferons lysozymes interleukin 2
Virus-infected cells produce interferons, proteins that help neighboring cells fight further viral infections.
What are interferons?
Interferons (IFNs) are a group of signaling proteins made and released by host cells in response to the presence of several pathogens such as viruses, bacteria, parasites, and tumor cells. The primary role of interferons is to signal and activate immune cells such as natural killer cells, macrophages, and T-cells to defend the body against pathogens. They also have antiviral, antibacterial, antitumor, and immunomodulatory properties that prevent virus replication and help clear the infection.
Interferons are classified into three categories based on their structure, mode of action, and the cells that produce them:
Type I interferons: They are produced by almost all cells in the body, including fibroblasts, leukocytes, and epithelial cells. They include IFN-α, IFN-β, IFN-ε, IFN-κ, and IFN-ω.
Type II interferons: They are mainly produced by T-cells and natural killer cells. They include IFN-γ.
Type III interferons: They are produced by epithelial cells and leukocytes. They include IFN-λ1, IFN-λ2, and IFN-λ3.
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describe how a non-resistant Staphylococcus aureus bacterium can produce a bacterium that is resistant to methicillin
Explanation:
characteristics of enzymes
S. aureus can develop resistance to methicillin and other -lactam antibiotics by expressing a foreign PBP, PBP2a, which is resistant to methicillin but can perform the functions of the host PBPs.
What is Staphylococcus aureus?Staphylococcus aureus is a Gram-positive round-shaped bacterium that pertains to the Bacillota and is a popular member of the body's microbiota, commonly found in the upper respiratory tract and on the skin.
S. aureus can develop resistance to methicillin and other -lactam antibiotics by expressing a foreign PBP, PBP2a, which is resistant to methicillin but can perform the functions of the host PBPs.
Thus, in this way a non-resistant Staphylococcus aureus bacterium can produce a bacterium that is resistant to methicillin.
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what is the word for a sequence of steps used to define and solve a problem
Answer:
Algorithm
Explanation:
Algorithm is the process that requires steps. Say for instance you are walking to school, and you don't want to step on a crack. You simply will step over one, and keep on going till you reach school. That's an algorithm.
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Explain the mistake you see in image 1
Cytoplasm should be present inside the cell.
Which biome has no trees and is frozen year round?
A tundra
B taiga
C desert
D grassland
Answer:
tundra
Explanation:
tree growth is hindered specifically by low temperatures
What are some ways that natural selection equips organisms for survival in their environment?
Answer:
Well organisms who have traits that are beneficial to them and would make them live long enough to usually reproduce, it would become an adaptive trait. That organism who has that trait will most likely live the longest and reproducing which will pass down their traits. Other same type of organisms who don’t have that trait will most likely die quicker then those who do and they won’t be able to pass on their genes which will lead to the natrual selection being very few of those types. If your born with a non useful trait, you jsut pass it down, you can’t just have the ones that benefit you unless yoru parents have it. This is why at the ”end” there will be more with useful traits and barley any with non.