PLEASE HELP! huntington’s disease (HD) is prevalent South Africa. Most of the families with HD have Dutch or British ancestry, which suggests they inherited the European HD allele. HD is believed to have first arrived in South Africa more than 300 years ago when Dutch colonists settled into the Western Cape in the 1600s. Thus, the prevalence of HD in South Africa is the result of the founder effect.

Mutations in the HTT gene cause Huntington’s disease. The HTT gene provides instructions for making a protein called huntintin. This protein plays a role in nerve cells in the brain. The HTT mutation that causes HD involves a DNA segment known as a CAG trinucleotide repeat. This segment is made up of a series of three DNA building blocks that appear multiple times in a row. Normally, the CAG segment is repeated 10 to 35 times within the gene. In people with HD, the CAG segment is repeated 36 to more than 120 times. An increase in the size of the CAG segment leads to the production of an abnormally long version of the huntintin protein. This causes the dysfunction and eventual death of neurons in certain areas of the brain. The more repeats, the more serious the disease is.

HD is inherited in an autosomal dominant pattern. There is both an adult onset (after reproductive age) and a juvenile onset pattern. People with adult onset typically have 40 to 50 repeats, while people with the juvenile form tend to have more than 60 repeats. Individuals who have 27 to 35 repeats do not develop HD, but they are at risk of having children who will develop the disorder. As the gene is passed on to offspring, the size of the repeat may lengthen into the range associated with HD.

Predict what will happen to the allele frequencies for Huntington’s disease in South Africa if there were a new mutation to the HTT gene that causes a reduction to the CAG trinucleotide repeat. Justify your prediction with evidence. Your response should include links to the sources of information gathered.

Answers

Answer 1

Answer:

If there were a new mutation to the HTT gene that causes a reduction to the CAG trinucleotide repeat, the allele frequency for Huntington's disease would decrease in South Africa. HD is caused by too many repeats of the CAG segment causing an abnormally long version of the huntintin protein which becomes deadly. so if the number of repeats is reduced then the person is more likely to not have Huntington's disease. If they do still develop Huntington's disease, it will be more likely to be adult onset and they will still have an opportunity to reproduce offspring which may carry the trait for reduced CAG.


Related Questions

Down syndrome can be observed in a karyotype/karyogram Xray frameshift point mutation

Answers

Down syndrome can be observed in a O karyotype/karyogram O X ray O frameshift point. DNA replication is necessary for all the responses are correct O growth

4. As food travels through the digestive system, it is exposed to a variety of pH
levels. The stomach has a pH of 2 due to the presence of hydrochloride acid (HCI),
and the small intestine has a pH ranging from 7 to 9. HCI converts pepsinogen into
pepsin, an enzyme that digests proteins in the stomach. Which of the following most
likely happens to pepsin as
it enters the small intestine?
A. It becomes inactive.
B. It begins to replicate.
C. It's shape changes to engulf large proteins.
D. It's activity increases
to digest more proteins.

Answers

A, it becomes inactive, it is no longer effective in the small intestines

where would you except to find the most of the sedimentary rocks on earth

Answers

Chemical sedimentary rocks can be found in many places, from the ocean to deserts to caves. For instance, most limestone forms at the bottom of the ocean from the precipitation of calcium carbonate and the remains of marine animals with shells.

The region identified by location 4 on the map is classified as belonging to the tundra biome. Which of the following climate graphs most accurately depicts the conditions found in this biome?
A
B
C
D

Answers

Answer:

B

Explanation:

For more proof look at the second image

Sudden infant death syndrome, preterm births and low birth weights, respiratory problems, and cardiovascular problems are more common among the offspring of mothers who ______ during pregnancy.

Answers

Sudden infant death syndrome, preterm births and low birth weights, respiratory problems, and cardiovascular problems are more common among the offspring of mothers who smoked during pregnancy.

Smoking during pregnancy can result in various different types of challenges during birth and mostly results in premature births, babies being born with low weights, or sudden infant death syndrome.

The lungs of infants whose mothers smoked during pregnancy are damaged which causes severe breathing problems in the child. It also causes the child to not develop properly and have respiratory or cardiovascular problems. Women who smoked during pregnancy can also cause severe complications to their own lives at the time of delivery.

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According to the law of superposition, fossils found at which position in these
layers of rock are likely to be the youngest?
Ο Α. Α
OB. B
О с. с
OD. D
ED
C
A
We
B

Answers

The law of superposition states that fossils found in the uppermost layers, i.e., layer A, are more recent than those found in the other layers, so option A is correct for the youngest fossil.

What is the fossil's importance?

When the environment changes due to climatic changes, animals or plants remain under the rocks, leaving their imprints or hard parts of their bodies, which are later studied to learn about ancestors. The fossils that are present in the lowermost rock layers are the oldest, while the uppermost layer is the youngest as it is newly formed.

As a result, the law of superposition states that fossils found in the uppermost layers, i.e., layer A, are more recent than those found in the other layers, so option A is correct for the youngest fossil.

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Free-floating periodontal pathogens can cause periodontal disease. Biofilm development always begins supragingival.
Select one:
A. Both statements are true
B. Both statements are false
C. The first statement is true; the second is false
D. The first statement is false; the second is true

Answers

The first statement is false, the second statement is true.

Which of the following statements about dinoflagellates is false?
A) They possess two flagella.
B) Some cause red tides.
C) their walls are composed of cellulose plates.
D) Many types contain chlorophyll.
E) Their fossil remains form limestone deposits.

Answers

The false statement about dinoflagellates is their fossil remains form limestone deposits.

Thus, the correct answer is E.

What are dinoflagellates?

Dinoflаgellаtes аre motile unicellulаr аlgаe chаrаcterized by а pаir of flаgellаe. Mаny dinoflаgellаtes аre photosynthetic, whereаs others аre mixotrophic. Whereаs most аre strictly mаrine, some dinoflаgellаtes occupy brаckish аnd freshwаter environments.

Dinoflаgellаtes аlso exhibit remаrkаble trаits: In аddition to chlorophyll, some possess cаrotenoid pigments (dinoxаnthin аnd peridinin), giving them а flаmboyаnt red colorаtion, whereаs others аre bioluminescent. Some species form blooms in the oceаns, а phenomenon cаlled “red tide” due to colorаtion of the wаter resulting from the intense concentrаtion of аlgаl cells. Dinoflаgellаtes аre encrusted with plаtes mаde of а cellulose-like mаteriаl аnd silicа.

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Which two conditions will contribute to the stability of drug-target interactions?
Options:
-The potential energy of the drug-target complex is at its lowest

-The shape of the drug molecule fits into the binding pocket of the target molecule

-The diffusion coefficient of the cell is very small

-The internal energy of the molecule is lower than the ambient temperature

Answers

Answer:

Two conditions that can contribute to the stability of drug-target interactions are:

-The shape of the drug molecule fits into the binding pocket of the target molecule. This allows the drug to interact with the target in a specific, complementary way, which can increase the stability of the complex.

-The potential energy of the drug-target complex is at its lowest. This means that the drug and target molecules are interacting in a way that minimizes the overall energy of the system, which can increase the stability of the complex.

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Explanation:

Which of the following best explains why triploid bananas do not produce seeds?
A) the cells of the banana plant are unable to replicated DNA, thus preventing cell division and limiting growth
B) the banana plants lack enough genetic diversity to properly hybridize
C) the production of gametes is disrupted because of unequal pairing of homologous chromosomes during meiosis
D) the production of seeds is not required because triploid plants produce gametes without fertilization

Answers

The following best explains why triploid bananas do not produce seeds: Banana cells are ill-suited to DNA replication, preventing cell division and limiting growth.

Triploid bananas are sterile and extremely sterile plants are barren. However, the banana fruit is produced without seeds and is a placental mammalian companion without fertilization or embryos.

A triploid plant does not produce viable seeds on its own, so the fruit is seedless. Successful seed set is truly rare, as triploids rarely produce eggs or sperm with a balanced set of chromosomes. Bananas, too, are parthenocarpic and produce fruit in the lack of successful fertilization. These triploid bananas reproduce asexually.

Occasionally, triploid banana plants produce mutants. This is an inherited defect that carries her three copies of every chromosome, rendering new plants unable to produce viable seeds.

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The letters in the diagram below represent genes on a particular chromosome.
Gene B contains the code for an enzyme that cannot be synthesized unless gene A is also active. Which statement best explains why this can occur?
(1) A hereditary trait can be determined by more than one gene.
(2) Genes are made up of double-stranded segments of DNA.
(3) All the genes on a chromosome act to produce a single trait.
(4) The first gene on each chromosome controls all the other genes on the chromosome.

Answers

More than one gene may contribute to a genetic trait.

Polygenic Character

A trait that is influenced by two or more genes, such as height or skin tone, is referred to as a polygenic trait. Polygenic traits do not follow the laws of Mendelian inheritance since several genes are involved.

Multifactorial traits are many polygenic qualities that are additionally influenced by the environment.

Multigenic trait We've discovered that the genetic component of many of the most significant health conditions of our time, such as cancer, heart disease, and diabetes, is caused by the interactions of many different genes as we've gotten better at identifying regions of the human genome that are associated with disease and at analyzing complex genomic data. Thus, polygenic, or having numerous genes. Studying these problems has been exciting since it has revealed how much may be done to improve human health by using the methods currently available to forecast the hazards associated with polygenic features.

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Which of the below terms would be different if the reflex were a balance reflex? What term would you substitute?
Pain receptor, sensory neuron, spinal cord, motor neuron, & effector muscle.

Answers

Answer:you i am minon pituf an red

Explanation:

Describe THREE ways in which applied anthropology can use the perspectives,
methods, and data of the differrent sub-fields of anthropology to help solve real-
world problems.

Answers

By researching cultures where particular social interactions are less contentious. understanding what, in a sense, makes a society or a group of people tick Will provide insight into how these linkages work.

Why should one study anthropology?

The detailed investigation of humans is known as anthropology, and its objectives include gaining an understanding of human evolution, our uniqueness as a race, and the wide variety of human societal systems that have existed across history of mankind and now.

What, for instance, is anthropology?

Anthropologists and people who conduct study team concentrate on the traits that define what it is to be a person. One anthropologist would look at the mating habits of a small community in New Guinea, whereas another might look into mating habits at a university. Humanity research is crucial.

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based on the information provided in the passage, which of the following best describes the effect of harmful algal blooms on otter populations?

Answers

'They are a density-independent factor that negatively affects the otter population regardless of its size' best describes the effect of harmful algal blooms on otter populations.

What are Algal blooms?

Algal blooms are large concentrations of aquatic microorganisms, primarily algae, that can occur in freshwater and marine ecosystems. They can range in color from green to yellow, brown, or red. Algal blooms are caused by an overgrowth of algae due to an abundance of nutrients, such as phosphorus and nitrogen, that are released into the water from sources such as agricultural runoff, sewage, and fertilizer. While some algal blooms are harmless, others can produce toxins that can be harmful to humans, wildlife, and the environment.

Hence, Option A is correct.

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Complete question:

Based on the information provided in the passage, which of the following best describes the effect of harmful algal blooms on otter populations?

A) They are a density-independent factor that negatively affects the otter population regardless of its size.

B) They are a density-independent factor that increases otter mortality in larger populations.

C) They are a density-independent factor that reduces otter numbers at lower population sizes.

D) They are a density-independent factor that increases otter mortality in only larger populations.

which of the following is found in the posterior mediastinum? group of answer choices thoracic duct heart right lymphatic duct primary bronchi thymus

Answers

The posterior thoracic mediastinum contains the descending aorta. A)Thoracic duct is found in posterior mediastinum. So, correct option is A.

The posterior Mediastinum is a sporadic three-sided space running lined up with the vertebral segment. The most striking blood vessel branches in this district are the proximal bits of the intercostal courses. It is limited in front by the pericardium above, and by the back surface of the stomach beneath, behind by the vertebral section from the lower boundary of the fourth to the twelfth thoracic vertebra, and on one or the other side by the mediastinal pleura.

It contains the thoracic piece of the dropping aorta, the azygos and the two hemiazygos veins, the vagus and splanchnic nerves, the throat, the thoracic pipe, and some lymph organs.

Hence, correct option is A.

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(Complete question) is:

which of the following is found in the posterior mediastinum? group of answer choices

a)thoracic duct

b)heart right lymphatic duct

c)primary bronchi

d)thymus

the pharmacogenetic profiling reveals a mutation in a cyp450 enzyme that causes increased enzyme activity. which of the statements below is incorrect? - There are variations in the enzymes as a result of genetic polymorphism
- It would require that the patient with this mutation is given greater than the standard dose of a drug if it is metabolized by this enzyme
- The profiling can be used to predict drug-drug interactions
- The CYP450 variants have no influence on drug metabolism

Answers

The CYP450 variants have no influence on drug metabolism.

How many different CYP450 subtypes exist?

Although there are more than 50 CYP450 enzymes, 90% of medicines are metabolized by CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP3A4, & CYP3A5 enzymes.These enzymes are mostly produced in the liver, although they are also found in the kidneys, placenta, lungs, small intestine (where they decrease medication bioavailability), and lungs.

Which CYP450 metabolizes medicines the fastest?

The most prevalently expressed responsible for the conversion enzyme in humans, CYP3A4, is in charge of breaking down more than 120 different drugs. As a result, it is crucial to research enzyme-based drug interactions.

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eweeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeewewee

Answers

Answer:ewe

Explanation:

ewe.

yup exactly true so true

Which of the following would be a reasonable conclusion if hair was found to have a drug in the middle of the strand but not in the rest of the hair strand?
Drug use is not identified.
Drug use is currently happening.
Drug use occurred several weeks ago.
Drug use has occurred for several months.

Answers

Answer:

drug use occurred several weeks ago.

Explanation:

Help me please on #4 I will mark brainzillest

Answers

Differentiated cells may look different but they have the same functions, the cells become grouped with similar cells result into formation of tissues, they make up tissues and organs of multicellular organisms. Thus, the correct option is B.

What is Cell differentiation?

Cellular differentiation or cell differentiation is the process through which a stem cell undergoes change from an undifferentiated form to a differentiated one. Usually, the cell changes to a more specialized type in this process.

The fundamental benefits of cellular differentiation includes the formation of more specialized and efficient cells which are involved in performing specific functions. For example, to ease water transport through the tracheary parts of the xylem, these cell loses its protoplasm and develops a lignified cell wall. The red blood cells in the living organisms which loose organelles to make more space for the hemoglobin pigment in the cell.

Therefore, the correct option is B.

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According to the Cell Theory, the is the basic unit of life; according to the Organismal Theory the is the basic unit.

Answers

Answer: The second part

Explanation:

The cell theory was proposed by Theodor Schwann in 1839. There are three parts to this theory. The first part states that all organisms are made of cells. The second part states that cells are the basic units of life.


Body Systems
Which body system
transports oxygen and
nutrients to the body and
aids in the removal of
carbon dioxide and other
waste products?

Answers

Answer:

it would be The circulatory system

Explanation:

because it said transports oxygen and it the circulatory carry blood away towards the heart.

NEED HELP DUE TOMORROW

Answers

Dependent variable is the amount of dirt and independent variable is the type of detergent used.

What are variables?

Variables are defined as any characteristics, number or quantity which can be measured . It can also be called as a data item . It is called as variable because they can vary and can have variety of values.

There are three types of variables 1) manipulated variable where in a condition is specified, 2) responding variable which is dependent on manipulated variable 3)controlled variable which do not change

Example of manipulated variables are number of hours spent by a student studying , that of responding variable is result of a student and temperature is an example of controlled variable.

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The _____ control(s) the force of a movement, whereas the_____ control(s) the timing and accuracy of the movement.a.motor cortex; basal gangliab.basal ganglia; motor cortexc.basal ganglia; cerebellumd.cerebellum; basal ganglia

Answers

The basal ganglia A movement's force is controlled by the cerebellum, while its timing and accuracy are controlled by the cerebellum.

What determines a movement's force?

The Motor Complex The brain is in charge of all voluntary actions of the body. The motor cortex is one of the parts of the brain that is most crucial in regulating these voluntary movements.

What function does the basal ganglia play in motor control?

The network of brain cells and nerves that manages your body's voluntary motions includes the basal ganglia as a significant component. Your brain sends movement signals that they can either approve or reject, screening away erroneous or superfluous impulses.

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If you were a subject in a scientific study measuring body fatness, the scientists might assess your anthropometric measurements using one of a variety of methods. Determine which method is being explained and drag the method description to its appropriate classification category You are placed in a chamber that measures body volume by measuring the volume of you displace while sittin Inside the chamber You stand on a scale placing your bare feel on the metal contact pants on the device The ansaw level electual current oth you cautions of percent body Balare made based on the concept than body mass conducts current and al mass resists Current
You lie on your back and a machine distributing low levels of radiation scans over you calculating percentages of tat lean issue, and bone mass You are weighed on a standard scale and then weighed again while submerged in water, the difference between the two weight is used to estimate total body volume A clinician uses fat calipers to measure the layer of a directly under the skin from a number of points on your body

Answers

You are placed in a chamber that measures body volume by measuring the volume of you displace while sitting inside the chamber: Hydrostatic weighingYou stand on a scale placing your bare feet on the metal contact points on the device: Bioelectrical impedance analysisYou lie on your back and a machine distributing low levels of radiation scans over you calculating percentages of fat, lean tissue, and bone mass: Dual-energy x-ray absorptiometryYou are weighed on a standard scale and then weighed again while submerged in water, the difference between the two weight is used to estimate total body volume: Hydrostatic weighingA clinician uses fat calipers to measure the layer of fat directly under the skin from a number of points on your body: Skinfold thickness measurement

In the process of , DNA is used as a template for making another type of nucleic acid called . The process begins when the enzyme binds to a region called the .


Answers

In the process of transcription, DNA is used as a template for making another type of nucleic acid called RNA. The process begins when the enzyme RNA polymerase binds to a region called the promotor.

What is transcription?

Transcription is a genomic process in which RNA is generated from DNA. This will generate an mRNA that will contain the genetic information of the protein that the gene encodes.

Transcription will be generated in the nucleus of the cell, there the RNA polymerase will bind to the DNA in the promoter to begin to generate the RNA copy, generating a transcription bubble to generate the RNA.

The transcription is preceded by the traduction that will take place in the cytoplasm of the cell to generate proteins from the mRNA.

Therefore, we can confirm that in the process of transcription, DNA is used as a template for making another type of nucleic acid called RNA. The process begins when the enzyme RNA polymerase binds to a region called the promotor.

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a mutation in the HBB gene,which codes for hemoglobin , produces red blood cells that are rigid and sickle shaped (is that beneficial, neutral, or harmful

Answers

Answer: harmful

Explanation:


Normally, red blood cells are flexible and oval-shaped, which allows them to move easily through the blood vessels and deliver oxygen to the body's tissues. However, sickle-shaped red blood cells are inflexible and can become stuck in small blood vessels, blocking the flow of blood and oxygen. This can cause a range of serious health problems, such as pain, infection, organ damage, and even death.

This plant group does not require water for sexual reproduction. this plant group does not require water for sexual reproduction. nonvascular plants seedless vascular plants seed vascular plants all of the above none of the above

Answers

because it is having asexual reproduction

If a strand of hair has a continuous medulla pattern, and the Medulla Index is 42, what species would it most likely be from?
Cat
Insect
Human
Polar Bear

Answers

Polar bear because it’s white

Answer:

It's a cat

Explanation:

I got it correct on my exam.

When the medulla index is above 33 and has a continuous pattern it's animal hair.

which of the following is not true about the cell membrane

Answers

Phospholipid heads are negative and attracted to water is not true about the cell membrane.

The heads aren’t the same thing they are a bit different than what you see at the end and the end but the head has a lot to do with the shape of the head and the shape of the body and the shape it is in the body and the body is the

the feeling that ejaculation can no longer be controlled is called ejaculatory: a. intervention. b. inevitability. c. excitement. d. orgasm.

Answers

the feeling that ejaculation can no longer be controlled is called ejaculatory: b. inevitability
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